Polynucleotide treatments have rapidly grown in popularity across the aesthetics sector, celebrated for their regenerative power and natural approach to skin revitalisation. Originally developed within medical and pharmaceutical research, polynucleotides have now found their place in modern beauty clinics, where they are praised for their ability to hydrate, heal and rejuvenate the skin at a cellular level. For those seeking subtle enhancement without invasive procedures, these treatments offer a compelling blend of science and aesthetics.
In this post, we’ll explore the different types of polynucleotide treatments available in the beauty and aesthetics industry, how they work, and the benefits they bring to skin health and appearance.
What Are Polynucleotides?
Polynucleotides are naturally occurring biopolymers made from nucleotides, the basic building blocks of DNA and RNA. In aesthetic treatments, they are extracted, purified and injected into the skin to stimulate tissue repair, increase hydration and improve overall skin structure. These molecules have the unique ability to support skin regeneration from within, encouraging fibroblast activity and improving microcirculation.
Unlike dermal fillers that volumise the skin with hyaluronic acid, polynucleotides act more like bio-revitalisers. They repair tissue damage, reduce inflammation and promote cellular renewal, making them ideal for patients who want gradual, natural-looking improvements in skin texture, tone and elasticity.
The Different Types of Polynucleotide Treatments
1. PN Injections (Polynucleotide-based Biorevitalisation)
This is the most common type of polynucleotide treatment. PN injections are typically administered via mesotherapy techniques, delivering the product directly into the dermis. These treatments are often used on the face, neck and décolletage, and are suitable for all skin types.
They are especially effective for improving skin quality in delicate areas such as under the eyes or the back of the hands. Patients often report firmer, more hydrated skin with reduced fine lines and a noticeable glow after a course of treatments.
2. PDRN (Polydeoxyribonucleotide) Treatments
A specific type of polynucleotide derived from salmon DNA, PDRN is widely used in regenerative medicine and aesthetic dermatology. It helps restore damaged tissue and is known for its anti-inflammatory and wound healing properties.
In aesthetic practice, PDRN is often combined with microneedling or delivered through skin boosters. It improves the appearance of acne scars, rosacea and photoaged skin. PDRN also supports vascularisation and boosts collagen synthesis, making it a trusted option for skin repair and anti-ageing.
3. Polynucleotide Skin Boosters
Skin boosters enriched with polynucleotides provide an all-in-one approach to hydration, repair and luminosity. These treatments are often used as maintenance therapies after more intensive rejuvenation procedures.
They suit younger patients looking for early prevention and older clients who want to enhance skin quality without altering facial structure. Commonly applied across the cheeks, forehead and periorbital areas, skin boosters bring about long-lasting skin tone improvement and a fresher appearance.
4. Polynucleotide Eye Treatments
The under-eye area is particularly delicate and often one of the first places to show signs of fatigue or ageing. Specially formulated polynucleotide treatments are used here to tackle dark circles, fine lines and crepey skin.
By enhancing microcirculation and strengthening the dermal layer, these treatments reduce puffiness and create a brighter, smoother look. Unlike filler, which can sometimes cause puffiness or migration, polynucleotides offer a safer alternative for the periorbital region.
5. Scalp and Hair Restoration Polynucleotides
A newer but growing category in aesthetic medicine is polynucleotide therapy for the scalp. These treatments target thinning hair and promote follicular health by improving circulation and repairing skin damage on the scalp.
They are often combined with microneedling or PRP to create an enhanced regenerative environment for hair growth. Early studies and anecdotal results suggest that polynucleotides can reduce hair shedding and improve overall scalp condition.
Benefits of Polynucleotide Aesthetic Treatments
Polynucleotide treatments deliver numerous benefits for skin and scalp health. Their regenerative potential goes beyond surface hydration to improve cellular function deep within the dermis. They are biocompatible and well tolerated, making them an excellent choice for patients who prefer minimal risk and low downtime.
Benefits include:
• Enhanced hydration from within
• Reduction in fine lines and wrinkles
• Improved skin tone, elasticity and firmness
• Revitalisation of tired, dull or stressed skin
• Support for collagen and elastin production
• Accelerated healing post-laser or microneedling treatments
• Reduction in under-eye puffiness and pigmentation
• Strengthening of scalp health and hair follicles
Whether used as a standalone therapy or alongside other treatments like PRP, microneedling or laser, polynucleotides are redefining how we approach non-invasive aesthetic enhancement. They offer a new standard in skin regeneration with results that build over time and provide a refreshed, healthy and youthful look.
